| Autor: |
Hirayama, Fumitoshi, Hirashima, Naoki, Abe, Kentaro, Uekama, Keneto, Ijitsu, Takanori, Ueno, Masao |
| Zdroj: |
Journal of Pharmaceutical Sciences; March 1988, Vol. 77 Issue: 3 p233-236, 4p |
| Abstrakt: |
Heptakis(2,6-di-Oethyl)-β-cyclodextrin (2) was prepared and its physicochemical properties, such as aqueous solubility and surface activity, were compared with those of β-cyclodextrin (1) and heptakis(2,6-di-Omethyl)-β-cyclodextrin (3). A possible utility of 2 as a sustained-release drug carrier was examined using a water-soluble drug, isosorbide dinitrate. The dissolution and release rates of isosorbide dinitrate from capsule and tablet forms were significantly retarded by the complexation with 2. The sustained-release pattern of isosorbide dinitrate was produced for a long period after the oral administration of a single dose of capsule or tablet containing the 2 complex to rats. The results indicated that 2 may serve as a hydrophobic drug carrier for sustained-release of isosorbide dinitrate. |
| Databáze: |
Supplemental Index |
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