Response of Pulmonary Mechanics to Terbutaline in Patients with Bronchopulmonary Dysplasia

Autor: Brudno, D. Spencer, Parker, Donald H., Slaton, Glenn
Zdroj: The American Journal of the Medical Sciences; March 1989, Vol. 297 Issue: 3 p166-168, 3p
Abstrakt: Terbutaline was administered to eight ventilator-dependent infants with evolving bronchopulmonary dysplasia to determine the potential for reductions in airway resistance. The drug was administered by nebulization through the endotracheal tube. Pre-treatment and post-treatment pulmonary mechanics measurements were performed. Patients had reductions in inspiratory (–14%, p = NS), expiratory (–47%, p < .05) and total (–24%, p = NS) resistances. Tidal volume increased 36% (p < .01). This study demonstrates that nebulized terbutaline can improve pulmonary mechanics in ventilator-dependent infants with evolving bronchopulmonary dysplasia.
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