| Autor: |
Kamel, Azza M., El-Sharkawy, Nahla M., Osman, Randa A., Abd El-Fattah, Eman K., El-Noshokaty, Essam, Abd El-Hamid, Thoraya, Kandeel, Eman Z. |
| Zdroj: |
Journal of the Egyptian National Cancer Institute; March 2016, Vol. 28 Issue: 1 p31-37, 7p |
| Abstrakt: |
B-cell chronic lymphocytic leukemia (CLL) is marked by the accumulation of CD5+ B lymphocytes within the blood, bone marrow (BM), and secondary lymphoid tissues. Abnormalities in the expression and function of cell adhesion molecules may account for the patterns of intra-nodal growth and hematogenous spread of the malignant cells. Chemokines and integrin-mediated adhesion and trans-endothelial migration (TEM) are central aspects in trafficking and retention of hematopoietic cells in the BM and lymphoid organs. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
|
