The Effects of Fentanyl and Morphine on Local Blood Flow and Oxygen Tension in the Frontoparietal Cortex and Nucleus Accumbens of the Brain in White Rats

Autor: Nikolaishvili, L., Gobechiya, L., Mitagvariya, N.
Zdroj: Neuroscience and Behavioral Physiology; June 2004, Vol. 34 Issue: 5 p467-471, 5p
Abstrakt: Studies on white rats showed that intraperitoneal administration of small doses of fentanyl (0.005 mg/kg) and morphine (1 mg/kg) decreased local blood flow and increased partial pressure of oxygen (pO2) in the frontoparietal area of the cerebral cortex but had the opposite effects in the nucleus accumbens – where there was a significant increase in local blood flow and just as significant a decrease in pO2. Analysis of the data led to the conclusion that these changes must result from significant changes in functional-metabolic activity in these structures, induced by intraperitoneal administration of fentanyl or morphine.
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