| Autor: |
Nguyen, Linh, Ramanathan, Murali, Munschauer, Frederick, Brownscheidle, Carol, Krantz, Susan, Umhauer, Margaret, Miller, Colleen, DeNardin, Ernesto, Jacobs, Lawrence |
| Zdroj: |
Journal of Clinical Immunology; May 1999, Vol. 19 Issue: 3 p179-185, 7p |
| Abstrakt: |
The cytokines, interferon-γ (IFN-γ), tumor necrosis factor-α (TNF-αrpar;, and interleukin-2 (IL-2) are important endogenous proinflammatory proteins and have been linked to disease activity in multiple sclerosis. In this study, we use flow cytometric methodology to compare the secretion of IFN-γ, IL-2, and TNF-α from peripheral blood-derived T cells of multiple sclerosis patients to the secretion in healthy controls. The percentages of IFN-γ, IL-2, and TNF-α secreting cells are not significantly different between multiple sclerosis patients and controls. However, the TNF-α secreting CDS cell percentage is correlated with the IFN-γ and IL-2 secreting CD3 cell percentages in multiple sclerosis patients. In the controls, only the TNF-α secreting CD3 cell percentage is correlated with IFN-γ. These findings show that correlated secretion of cytokines occurs in multiple sclerosis and suggest that concerted intercytokine interactions may play an important role in the disease. |
| Databáze: |
Supplemental Index |
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