| Autor: |
Kim, Mi-Sun, Na, Ho-Jeong, Han, Seung-Woo, Jin, Jong-Sik, Song, Un-Yong, Lee, Eon-Jeong, Song, Bong-Keun, Hong, Seung-Heon, Kim, Hyung-Min |
| Zdroj: |
Inflammation; June 2003, Vol. 27 Issue: 3 p129-135, 7p |
| Abstrakt: |
Mast cells are key as effector cells in the early phase allergic inflammation and in diverse immunological and pathological processes. Forsythia fructus (F. fructus)has used as a traditional medicine for inflammatory diseases. In the present study, we determined the effect of F. fructusextracts on compound 48/80-induced paw oedema and vascular permeability in vivo. In addition, we investigated in vitrowhether F. fructushas inhibitory effects on compound 48/80-induced histamine releases from rat peritoneal mast cells (RPMC), and on phorbol 12-myristate 13-acetate (PMA) plus A23187-induced tumor necrosis factor-α (TNF-α) releases from human mast cells (HMC-1). In mice orally administrered F. fructus(100 μg/g) for 1 h, compound-48/80-induced oedema and vascular permeability were significantly reduced rather than those receiving intravenous injection of ketotifen, mast cell stabilizer. F. fructusdose-dependently inhibited the histamine release induced by compound 48/80 from RPMCs. Moreover, F. fructushad no cytotoxic effects on cell viability and had inhibitory effects on TNF-α secretion from HMC-1. These results suggest that F. fructusis a potential herb medicine for treatment of inflammatory diseases through downmodulating mast cell activation. |
| Databáze: |
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