| Autor: |
Wiley, Thelma, Briedi, Lama, Lam, Nancy, Layden, Thomas |
| Zdroj: |
Digestive Diseases and Sciences; October 1998, Vol. 43 Issue: 10 p2169-2172, 4p |
| Abstrakt: |
The aim of this study is to determine inpatients infected with hepatitis C virus (HCV) whetherearly HCV RNA measurements at 48 hr following standarddoses of interferon-α (IFN-α) (3 million IU) would predict response during six months oftherapy. Twenty-three patients with HCV were treatedwith IFN-α 3 million IU three times a week and HCVRNA levels were quantified by branched-chain (b-)DNA analysis at baseline and 24 and 48 hr followingIFN-α and at one, three, and six months. Meanbaseline HCV RNA levels significantly declined from 6.0± 1.6 Meq/ml at baseline to 2.4 ± 0.7Meq/ml 24 hr after IFN-α. However, HCV RNAvalues increased to 4.3 ± 1.1 Meq/ml by 48 hr.Mean HCV RNA values at one and six months were notsignificantly lower than 48-hr values. In six patientsin whom HCV RNA was negative by bDNA at 48 hr, threewere negative by polymerase chain reaction at sixmonths. Of the 17 patients who were positive by bDNA at48 hr, all were positive at one and three months; and in the nine of nine who continued therapy forsix months, there was no further decrease in HCV RNAlevels. In patients receiving standard doses ofIFN-α (3 million IU), serum RNA values 48 hr after the first injection predict long-termresponse. |
| Databáze: |
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