| Autor: |
Manna, Partha, Jaramillo, Andrés, Majumder, Kanchana, Campbell, Lacey, Fleming, Timothy, Dietz, Jill, Dipersio, John, Mohanakumar, T. |
| Zdroj: |
Breast Cancer Research and Treatment; May 2003, Vol. 79 Issue: 1 p133-136, 4p |
| Abstrakt: |
Mammaglobin-A is exclusively expressed by breast cancer cells. Thus, mammaglobin-A-specific T cell immune responses may be useful for the design of new breast cancer-specific immunotherapies. We show herein that CD8+ T cells generated against recombinant mammaglobin-A-pulsed dendritic cells display a marked cytotoxic activity against mammaglobin-A-positive breast cancer cell lines. This study indicates the immunotherapeutic potential of this novel antigen for the treatment of breast cancer. |
| Databáze: |
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