Immunoprotective Effects of Prolactin during Stress-Induced Immune Dysfunction

Autor: Fomicheva, E., Nemirovich-Danchenko, E., Korneva, E.
Zdroj: Bulletin of Experimental Biology and Medicine; June 2004, Vol. 137 Issue: 6 p544-547, 4p
Abstrakt: We showed for the first time that prolactin stimulates the synthesis and release of immunomodulating cytokines and lymphocyte-activating factors (e.g., interleukin-1) by peritoneal macrophages. Prolactin abolished the stress-induced inhibition of proliferation of peripheral blood lymphocytes and increased cell sensitivity to regulatory effects of interleukin-1 in the reaction of lymphocyte blast transformation. These data illustrate the mechanism of immunoprotective activity of prolactin during stress.
Databáze: Supplemental Index