| Autor: |
Grigor'ev, V., Dranyi, O., Bachurin, S. |
| Zdroj: |
Bulletin of Experimental Biology and Medicine; November 2003, Vol. 136 Issue: 5 p474-477, 4p |
| Abstrakt: |
Dimebon in low concentrations potentiated activity of AMPA-receptors in rat cerebellar Purkinje neurons, while memantine produced only an insignificant potentiation in a small group of these cells. In cortical neurons of rat brain memantine efficiently blocked NMDA-induced currents in dimebon-insensitive neurons. By contrast, its effect was far weaker in neurons, where the blocking action of dimebon on NMDA-receptors was most pronounced. It was hypothesized that the differences in the effects of memantine and dimebon are determined by their interaction with different sites of NMDA-receptors. |
| Databáze: |
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| Externí odkaz: |
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