Cyclization of Nitriles: LIX. Synthesis and Properties of 1-(2-Thienyl)-4-cyano-5,6,7,8-tetrahydro-3(2H)- isoquinolinethione Derivatives. Molecular and Crystal Structure of 3-Isobutylsulfanyl-1-(2-thienyl)-4-cyano-5,6,7,8- tetrahydroisoquinoline

Autor:	Lozinskii, M., Chernega, A., Shelyakin, V.
Zdroj:	Russian Journal of Organic Chemistry; November 2002, Vol. 38 Issue: 11 p1661-1665, 5p
Abstrakt:	By condensation of 2-(2-thenoyl)-1-cyclohexanone with cyanothioacetamide a new compound of aseries of chalcogen-containing isoquinolines with a thiophene fragment in its structure was prepared. It wasdemonstrated that alkylation of the compound with haloalkanes, their derivatives, in particular with thosehaving electron-withdrawing substituents furnished 3-alkylthio-4-cyano-5,6,7,8-tetrahydroisoquinolines.Some of the latter underwent cyclization into 3-amino-2-R-5-(2-thienyl)-6,7,8,9-tetrahydrothieno[2,3-c]isoquinoline.
Databáze:	Supplemental Index
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