Synthesis and Immunomodulating Activity of New Amino Acid Derivatives of Glycyrrhizic Acid and Its Methyl Ester

Autor: Kondratenko, R., Baltina, L., Vasil'eva, E., Nasyrov, Kh., Kireeva, R., Baschenko, N., Fridman, S., Baltina, L., Tolstikov, G.
Zdroj: Russian Journal of Bioorganic Chemistry; March 2004, Vol. 30 Issue: 2 p148-153, 6p
Abstrakt: New amino acid derivatives of glycyrrhizic acid and its methyl ester were selectively synthesized using active N-succinimide esters. The compounds with residues of glycine ethyl ester and alanine methyl and butyl esters increased the level of agglutinins and hemolysins in blood serum of mice two- to threefold in comparison with the control upon parenteral administration at a dose of 2 mg/kg for 14 days.
Databáze: Supplemental Index