A putative marker for human pathogenic strains of Anaplasma phagocytophilumcorrelates with geography and host, but not human tropism

Autor: Foley, Janet, Stephenson, Nicole, Cubilla, Michelle Pires, Qurollo, Barbara, Breitschwerdt, Edward B.
Zdroj: Ticks and Tick-borne Diseases; March 2016, Vol. 7 Issue: 2 p390-393, 4p
Abstrakt: Anaplasma phagocytophilumis an Ixodesspecies tick-transmitted bacterium that is capable of infecting a variety of host species, although there is a diversity of bacterial strains with differing host tropism. Recent analysis of A. phagocytophilumstrains suggested that “drhm”, a gene locus designated “distantly related to human marker” (drhm), which was predicted to be an integral membrane protein with possible transporter functions was not present in available canine and human isolates. By assessing 117 strains from 14 host species from across the US, we extended this analysis. Phylogenetic clades were associated with geography, but not host species. Additionally, a virulent clade that lacks drhmand infects dogs, horses, and humans in northeastern US was identified.
Databáze: Supplemental Index