| Autor: |
Le´vesque, Sophie S., St-Denis, Yves Y., Bachand, Benoit B., Pre´ville, Patrice P., Leblond, Lorraine L., Winocour, Peter D. P.D., Edmunds, Jeremy J. J.J., Rubin, J.R., Siddiqui, M. Arshad M.A. |
| Zdroj: |
Bioorganic & Medicinal Chemistry Letters; 2001, Vol. 11 Issue: 24 p3161-3164, 4p |
| Abstrakt: |
Peptidomimetic inhibitors of thrombin lacking the important Ser195-carbonyl interaction have been prepared. The binding energy lost after the removal of the activated carbonyl was recaptured through a series of modifications of the P1 residues of the bicyclic lactam inhibitors. Selected substituted compounds displayed useful pharmacological profiles both in vitro and in vivo. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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