| Autor: |
Shin, Young Shik, Kim, Jungwoo, Johnson, Dazy, Dooraghi, Alex A., Mai, Wilson X., Ta, Lisa, Chatziioannou, Arion F., Phelps, Michael E., Nathanson, David A., Heath, James R. |
| Zdroj: |
TECHNOLOGY; December 2015, Vol. 3 Issue: 4 p172-178, 7p |
| Abstrakt: |
The most common positron emission tomography (PET) radio-labeled probe for molecular diagnostics in patient care and research is the glucose analog, 2-deoxy-2-[F-18]fluoro-D-glucose (18F-FDG). We report on an integrated microfluidics-chip/beta particle imaging system for in vitro18F-FDG radioassays of glycolysis with single cell resolution. We investigated the kinetic responses of single glioblastoma cancer cells to targeted inhibitors of receptor tyrosine kinase signaling. Further, we find a weak positive correlation between cell size and rate of glycolysis. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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