| Autor: |
Alfano, Dennis P., Petit, Ted L. |
| Zdroj: |
Experimental Neurology; February 1982, Vol. 75 Issue: 2 p275-288, 14p |
| Abstrakt: |
Previous evidence suggests an association between hippocampal dysfunction and the behavioral deficiencies observed in experimental animals following neonatal lead (Pb) exposure. This study was thus conducted to discern the possible effects of Pb on the dendritic development of hippocampal dentate granule cells. Long-Evans hooded rat pups were exposed to Pb from postnatal days 1 to 25 via the maternal milk. Mothers were fed diets containing either 4.0% PbCO3(high Pb), 0.4% PbCO3(low Pb), or a 2.2% Na2CO3control diet throughout this period. On postnatal day 30, pups from each group were randomly selected and their hippocampi processed with the rapid Golgi method. For analysis of dendritic development, granule cells from the infrapyramidal limb of the dentate gyrus were examined using the Scholl method. The maximal length and width of the dendritic field of these cells were also measured. The results of this study indicate not only increased dendritic branching at 20 μm from the cell body in low Pb-exposed animals, but also both a reduced length of the dendritic field and a reduction in the number of dendritic branches at distances greater than 160 μm from the cell body after both high or low Pb exposure. As such, these findings indicate that morphological changes in the development of the hippocampal formation may underlie many of the behavioral changes observed in experimental animals after neonatal Pb exposure. |
| Databáze: |
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