| Autor: |
Chen, Lukui, Zhang, Guilong, Shi, Yan, Qiu, Rong, Ali Khan, Ahsan |
| Zdroj: |
Current Pharmaceutical Design; November 2015, Vol. 21 Issue: 37 p5434-5449, 16p |
| Abstrakt: |
In this review, Neuropilin-1 (NRP-1) has been focused as a novel molecular target for potential treatment of gliomas. The properties of NRP-1 were described briefly. The role of NRP-1 in gliomas was explored in details, including relationships of NRP-1 expression and glioma prognosis, Sema3A-NRP-1 signaling in gliomas, NRP-1 signaling and VEGF/VEGFR128;PlGF128;TGF-β128;PDGF128;LD22-4 of FGF2128;autocrine of HGF/SF128;p130Cas tyrosine phosphorylation and integrin-associated tumor microenvironment in gliomas, NRP-1 intracellular trafficking, NRP-1 and glioma stem-like cells, as well as magnetic nanoparticles related to targeting gliomas. NRP-1, a multifunctional-receptors protein, would mediate diverse cellular signaling pathways in gliomas, and might potentially act as a novel therapeutic target. In future, magnetic nanoparticles coated with NRP-1 may play a vital role on diagnosis and therapy of gliomas. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
|
