| Autor: |
Alves, Márcia, Lamego, Joana, Bandeiras, Tiago, Castro, Rute, Tomás, Hélio, Coroadinha, Ana Sofia, Costa, Júlia, Simplício, Ana Luisa |
| Zdroj: |
Biochemistry and Biophysics Reports; March 2016, Vol. 5 Issue: 1 p105-110, 6p |
| Abstrakt: |
Human carboxylesterase 2 (hCES2) is a glycoprotein involved in the metabolism of drugs and several environmental xenobiotics, whose crystallization has been proved to be a challenging task. This limitation could partly be due to glycosylation heterogeneity and has delayed the disclosure of the 3D structure of hCES2 which would be of upmost relevance for the development of new substrates and inhibitors. The present work evaluated the involvement of glycans in hCES2 activity and thermo stability in an attempt to find alternative active forms of the enzyme that might be adequate for structure elucidation. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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