| Autor: |
Aono, Tatsuya, Sasagawa, Hisashi, Fuchibe, Kohei, Ichikawa, Junji |
| Zdroj: |
Organic Letters; 20240101, Issue: Preprints |
| Abstrakt: |
Silyl dienol ethers prepared from α,β-unsaturated ketones underwent nickel-catalyzed difluorocyclopropanation of the electron-rich alkene moiety with trimethylsilyl 2,2-difluoro-2-(fluorosulfonyl)acetate. The subsequent vinylcyclopropane–cyclopentene rearrangement afforded silyl 5,5-difluorocyclopent-1-en-1-yl ethers in good yields. The obtained five-membered silyl enol ethers were demonstrated to be versatile intermediates for the synthesis of di- and monofluorinated cyclopentanones and cyclopentenones. A nickel difluorocarbene complex is proposed as a key intermediate in the difluorocyclopropanation. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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