| Autor: |
Vucicevic, Ksenija, Jakovljevic, Vladimir, Sretenovic, Jasmina, Tosic, Natasa, Kostic, Tatjana, Glumac, Irena, Colovic, Milica, Colovic, Natasa, Pavlovic, Sonja, Karan-Djurasevic, Teodora |
| Zdroj: |
Serbian Journal of Experimental and Clinical Research; September 2015, Vol. 16 Issue: 3 p187-191, 5p |
| Abstrakt: |
Chronic lymphocytic leukaemia (CLL) manifests as clonal expansion of mature B lymphocytes, whose accumulation is primarily attributed to the dysregulation of apoptosis. Aberrant expression, as well as genetic alterations within various Bcl2 family members and central regulators of the intrinsic, mitochondria-mediated apoptotic pathway all hasve been observed in CLL. Here, we report the expression analysis of the anti-apoptotic Bcl2 gene in a cohort of 58 CLL patients. Quantitative reverse-transcriptase polymerase chain reaction (qRT-PCR) analysis revealed a significant overexpression of Bcl2 mRNA in CLL samples compared to control samples (p=<0.001). Receiver operating characteristic (ROC) analysis showed that the level of Bcl2 expression exerts a high discriminatory power between patients and healthy subjects (A=0.98, 95% CI=0.95-1.009, p<0.0001). |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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