| Autor: |
Walker, Kelly L, Jones, Alexander S, Robinson, Colin |
| Zdroj: |
Pharmaceutical Bioprocessing; October 2015, Vol. 3 Issue: 6 p387-396, 10p |
| Abstrakt: |
Approximately 30 of all currently licensed, recombinantly expressed biotherapeutic products are produced in Escherichia coli, among which a significant proportion are exported to the periplasm by the general Secretory ‘Sec’ pathway. However, this pathway cannot handle many target proteins and the Tat pathway is emerging as a powerful alternative means of export. The Tat system exports fully folded proteins, moreover it preferentially exports correctly folded proteins and has been shown to export a range of biotherapeutics. This review will discuss our current understanding of the Tat pathway and its potential application for the industrial-scale production of biotherapeutics. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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