Sensitivity of Contrast Ultrasound in the Detection of Atrial Septal Defect with Predominant Left-to-Right Shunting

Autor: Hajduczok, Zina D., Winniford, Michael D., Kerber, Richard E.
Zdroj: Journal of the American Society of Echocardiography; September-October 1992, Vol. 5 Issue: 5 p475-480, 6p
Abstrakt: Ultrasound contrast techniques are used widely as a screening test for intracardiac shunt. We performed a retrospective analysis of contrast echocardiograms in 29 consecutive patients with atrial septal defect (excluding Eisenmenger's) proved by cardiac catheterization. A positive (right-to-left atrial) ultrasound contrast effect was seen in 25 patients in whom catheterization pulmonary-to-systemic flow rate (Qp/Qs) was 2.2 ± 0.9 (SD). Four patients had false-negative constrast echocardiography results; their Qp/Qs was 2.9 ± 0.4 (p = 0.07). The percent left-to-right shunt was higher in the group with false-negative contrast echocardiographic results (65% ± 4% vs 47% ± 21%) (p= 0.05). Shunts with Qp/Qs ≤ 2.0 had a sensitivity of 100%, whereas those with Qp/Qs ≥ 2.1 had a sensitivity of 73%. In the four false-negative contrast echocardiographic results, three had findings of an atrial septal defect by pulsed Doppler, color Doppler, or both. Thus the presence of a large left-to-right shunt may decrease the sensitivity of the ultrasound contrast technique for the detection of an atrial septal defect. Contrast ultrasonography should be used in conjunction with Doppler and two-dimensional echocardiography criteria for diagnosis of atrial septal defect.
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