Autor: |
Eison, Arlene S., Mullins, U. Lena |
Zdroj: |
Behavioural Brain Research; 1995, Vol. 73 Issue: 1-2 p177-181, 5p |
Abstrakt: |
Numerous investigations have studied in vivo regulation of central 5-HT 2 A receptors. The majority of pharmacological studies point to non-classical regulation of this site. Serotonergic denervation does not modify 5-HT 2 A receptor density or second messenger responses (phosphoinositide hydrolysis). 5-HT 2 A receptor downregulation is produced by the chronic administration of 5-HT 2 A receptor agonists and uniquely among monoamine receptors by antagonists. Several classes of psychotherapeutic agents also downregulate 5-HT 2 A receptors with chronic administration including classical antidepressants and antipsychotics. 5-HT 2 A receptor downregulation produced by 5-HT 2 A antagonists and antidepressants occurs after presynaptic 5-HT denervation, suggesting that 5-HT 2 A receptors are postsynaptically localized and emphasizing that they are regulated differently than traditional monoaminergic receptors. Interestingly, the behavioral and biochemical effects of 5-HT 2 A receptor activation are modulated by activity at other 5-HT receptor subtypes (5-HT 1 A ), as well as by stimulation of receptors for other neurotransmitters and hormones such as norepinephrine (beta-adrenergic) and melatonin. It is suggested that these diverse modulatory influences on 5-HT 2 A receptor regulation and function may meaningfully impact the therapeutic actions of drugs, including pharmacologically distinct antidepressants. |
Databáze: |
Supplemental Index |
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