α1B-Adrenoceptor signaling molecule expression in Alzheimer’s disease brain tissue / Alzeimer hastalığı olan beyin dokusunda α1B-Adrenoseptör Sinyal Molekülü Ekspresyonu

Autor: Kim, Jin Hee, Lee, Sang Cheol, Lim, Jae Yong, Kim, Dong Seok, Yun, Hye Young, Kwon, Nyoun Soo, Im, Mie Jae, Baek, Kwang Jin
Zdroj: Turk Biyokimya Dergisi = Turkish Journal of Biochemistry; October 2015, Vol. 40 Issue: 5 p376-385, 10p
Abstrakt: Objective: Gαh (tissue transglutaminase; TGII), known as the α1B-adrenoceptor signal mediator, is a bifunctional enzyme possessing transglutaminase and guanosine triphosphatase activities. The microtubule-associated protein tau plays a role in formation of neurofibrillary tangles in Alzheimer’s disease (AD) brain. Tau is also known as a substrate of transglutaminase. We aimed to better understand the correlation between α1B-adrenoceptor signaling and AD.
Databáze: Supplemental Index