| Autor: |
Tazat, Keren, Hector-Greene, Melissa, Blobe, Gerard C., Henis, Yoav I. |
| Zdroj: |
Molecular Biology of the Cell; October 2015, Vol. 26 Issue: 19 p3535-3545, 11p |
| Abstrakt: |
Study of the TβRIII interaction with the signaling TGF-β receptors shows that TβRIII homo-oligomerization is indirect, depending largely on interactions with GIPC scaffolds. TβRI and II bind independently to TβRIII, competing with TβRI-TβRII complex formation and inhibiting Smad2/3 signaling by a mechanism independent of TβRIII ectodomain shedding. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
|
