| Autor: |
Wasserman, Lina, Beery, Einat, Aviram, Rami, Levavi, Hanoch, Ovadia, Jardena, Novogrodsky, Abraham, Nordenberg, Jardena |
| Zdroj: |
European Journal of Cancer and Clinical Oncology; December 1989, Vol. 25 Issue: 12 p1765-1768, 4p |
| Abstrakt: |
The effect of sodium butyrate was examined on the growth and phenotypic expression of a cell line derived from the ascitic fluid of an untreated patient with ovarian carcinoma. The chemical inducer of differentiation, sodium butyrate, markedly enhances the activity of the membrane-bound glycoprotein enzymes, alkaline phosphatase and γ-glutamyl transpeptidase. The alkaline phosphatase corresponds to placental Regan type. Sodium butyrate (1 mM) alone has only a small inhibitory effect on cell growth. However, it was shown to potentiate the anti-proliferative effect of Adriamycin®and to render the cells sensitive to cis-platinum. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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