| Autor: |
Wirjanata, Grennady, Sebayang, Boni F., Chalfein, Ferryanto, Prayoga, Handayuni, Irene, Trianty, Leily, Kenangalem, Enny, Noviyanti, Rintis, Campo, Brice, Poespoprodjo, Jeanne Rini, Möhrle, Jörg J., Price, Ric N., Marfurt, Jutta |
| Zdroj: |
Antimicrobial Agents and Chemotherapy; July 2015, Vol. 59 Issue: 10 p6117-6124, 8p |
| Abstrakt: |
ABSTRACTThe 4-aminoquinoline naphthoquine (NQ) and the thiazine dye methylene blue (MB) have potent in vitroefficacies against Plasmodium falciparum, but susceptibility data for P. vivaxare limited. The species- and stage-specific ex vivoactivities of NQ and MB were assessed using a modified schizont maturation assay on clinical field isolates from Papua, Indonesia, where multidrug-resistant P. falciparumand P. vivaxare prevalent. Both compounds were highly active against P. falciparum(median [range] 50% inhibitory concentration [IC50]: NQ, 8.0 nM [2.6 to 71.8 nM]; and MB, 1.6 nM [0.2 to 7.0 nM]) and P. vivax(NQ, 7.8 nM [1.5 to 34.2 nM]; and MB, 1.2 nM [0.4 to 4.3 nM]). Stage-specific drug susceptibility assays revealed significantly greater IC50s in parasites exposed at the trophozoite stage than at the ring stage for NQ in P. falciparum(26.5 versus 5.1 nM, P= 0.021) and P. vivax(341.6 versus 6.5 nM, P= 0.021) and for MB in P. vivax(10.1 versus 1.6 nM, P= 0.010). The excellent ex vivoactivities of NQ and MB against both P. falciparumand P. vivaxhighlight their potential utility for the treatment of multidrug-resistant malaria in areas where both species are endemic. |
| Databáze: |
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