| Abstrakt: |
A total of 411 selected patients with varying degrees of dysplasia and in situ carcinoma were followed by cytology alone for varying intervals of time before tissue diagnosis was felt necessary or was established by conization. Results reveal the following: (1) Mild or moderate dysplasia is an unstable process—31 per cent of the cases regressed, 8.9 per cent remained stable, and 60.1 per cent progressed in a group of 278 patients. (2) Carcinoma in situ is a stable process in comparison with dysplasia. It rarely regresses and may persist as such for long periods of time. Thirty-three of 133 patients were followed for periods of 15 to 90 months without invasion. (3) The onset of dysplasia and in situ carcinoma may be reasonably abrupt. Seventy patients of 134, with previously negative cytology within the preceding 12 months, showed dysplastic or in situ changes. (4) Invasive carcinoma apparently is preceded by in situ carcinoma and dysplasia in most cases. |
