| Autor: |
Wieland, Ralph G., Vorys, Nichols, Folk, Robert L., Hamwi, George J. |
| Zdroj: |
American Journal of Obstetrics and Gynecology; October 1967, Vol. 99 Issue: 4 p489-494, 6p |
| Abstrakt: |
The group of hirsuite females who had an initial elevation of testosterone glucuronoside (TG) excretion which decreased acutely with adrenocortical suppression was studied during chronic suppression. Testosterone excretion remained in the normal female range. This was accompanied by clinical improvement in 6 of 7 patients. That ovulation was indeed occurring after treatment was difinitely demonstrated in one patient by repeating the culdoscopy. The conversion rate of androstenedione (Δ),the immediate blood testosterone (T) precursor, to TG in patients with this pattern of testosterone excretion was similar to that observed in hirsute females with normal urinary TG and in females without endocrinologic disease. Increased adrenal secretion of T precursors or of T would seem to best explain the abnormalities in these patients. Measurement of T precursors in the adrenal effluent from a patient with Cushing's syndrome revealed no adrenal epitestosterone (Epi T) production although large amounts of dehydroepiandrosterone (D) and dehydroepiandrosterone sulfate (DS) were secreted. Free and sulfated urinary T fractions were quantitatively insignificant in the group of women studied with unexplained hirsutism and either normal or increased TG excretion. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
|
