Lecithin/sphingomyelin ratio in amniotic fluid and its value for the prediction of neonatal respiratory distress syndrome in pregnant diabetic women

Autor: Mueller-Heubach, Eberhard, Caritis, Steve N., Edelstone, Daniel I., Turner, J. Howard
Zdroj: American Journal of Obstetrics and Gynecology; January 1978, Vol. 130 Issue: 1 p28-34, 7p
Abstrakt: In 101 diabetic pregnant women (Classes A through D) 146 determinations of the lecithin/sphingomyelin (L/S) ratio were carried out. Gestational ages were verified by serial fetal cephalometry. NoL/Sratios of more than 2.0 were found before341/2weeks' gestation; however, in 42 per cent of patients theL/Sratio was below 2.0 at 36 weeks' gestation or later. Respiratory distress syndrome (RDS) was found in 16 neonates of women withL/Sratios of 2.0 or higher; however, RDS incidence varied depending on the mode of delivery. Abdominal delivery was performed before 37 weeks' gestation in 19 patients withL/Sratios of 2.0 or higher and resulted in neonates with RDS in 41 per cent of cases. Vaginal delivery was accomplished before 37 weeks' gestation in 10 patients withL/Sratios of 2.0 or higher and no subsequent neonatal RDS was observed. After 37 weeks' gestation neonatal RDS is rare, irrespective of mode of delivery. The data presented suggest that similar numerical values of theL/Sratio at different gestational ages have a different predictive value for the occurrence of neonatal RDS.
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