Experimental Investigation of 99mТс-Nanotech Used for Lymph Nodes Visualization

Autor: Sinilkin, Ivan, Chernov, Vladimir, Titskaya, Anna, Zelchan, Roman, Daneikina, Natalya
Zdroj: Advanced Materials Research; January 2015, Vol. 1084 Issue: 1 p389-392, 4p
Abstrakt: Measurement of colloidal particles size was performed on a NICOMP 380 ZLS. Pharmacokinetics. Radiometry of the organs was carried out on γ-spectrometer. Measurement of the sizes of radioactive particles of 99mTc-nanotech showed that average dynamic diameter of RFP particle ranged from 16.7 to 24.5 nm. 99mTc-nanotech received by the blood is actively trapped by liver and spleen. Inguinal lymph node in all animals was clearly visualized during lymphoscintigraphy on the 15th minute. Maximum accumulation of 99mTc-nanotech was observed in 3 hours. Experimental study of radiopharmaceutical 99mTc-nanotech showed that the nanocolloid can be used for lymphoscintigraphy and visualization of “sentinel” nodes.
Databáze: Supplemental Index