| Autor: |
Januário, A. H., Filho, E. Rodrigues, Pietro, R. C. L. R., Kashima, S., Sato, D. N., França, S. C. |
| Zdroj: |
Phytotherapy Research; August 2002, Vol. 16 Issue: 5 p445-448, 4p |
| Abstrakt: |
Crude extracts and fractions from aerial parts of Physalis angulatahave been bioassayed for antimycobacterial activity. Fraction A1‐29‐12 containing physalins B, F and D exhibited a minimum inhibitory concentration value (MIC) against Mycobacterium tuberculosisH37Rv strain of 32 μg/mL. Purified physalin B and physalin D were also tested showing MIC values against Mycobacterium tuberculosisH37Rv strain of >128 μg/mL and 32 μg/mL respectively, suggesting that physalin D plays a relevant role in the antimycobacterial activity displayed. Structural elucidation of both physalins D and B was based on detailed 13C and 1H NMR spectral analysis with the aid of 2D‐correlation spectroscopy (1H‐1H, COSY, HSQC and HMBC). The assignment of the 13C chemical shift for physalin D is reported here for the first time. Copyright © 2002 John Wiley & Sons, Ltd. |
| Databáze: |
Supplemental Index |
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