| Autor: |
Chen, Feng, Goel, Shreya, Valdovinos, Hector F., Luo, Haiming, Hernandez, Reinier, Barnhart, Todd E., Cai, Weibo |
| Zdroj: |
ACS Nano; August 2015, Vol. 9 Issue: 8 p7950-7959, 10p |
| Abstrakt: |
Traditional chelator-based radio-labeled nanoparticles and positron emission tomography (PET) imaging are playing vital roles in the field of nano-oncology. However, their long-term in vivointegrity and potential mismatch of the biodistribution patterns between nanoparticles and radio-isotopes are two major concerns for this approach. Here, we present a chelator-free zirconium-89 (89Zr, t1/2= 78.4 h) labeling of mesoporous silica nanoparticle (MSN) with significantly enhanced in vivolong-term (>20 days) stability. Successful radio-labeling and in vivostability are demonstrated to be highly dependent on both the concentration and location of deprotonated silanol groups (−Si–O–) from two types of silica nanoparticles investigated. This work reports 89Zr-labeled MSN with a detailed labeling mechanism investigation and long-term stability study. With its attractive radio-stability and the simplicity of chelator-free radio-labeling, 89Zr-MSN offers a novel, simple, and accurate way for studying the in vivolong-term fate and PET image-guided drug delivery of MSN in the near future. |
| Databáze: |
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