| Autor: |
Abegaz, B. M., Bezabih, M., Msuta, T., Brun, R., Menche, D., Muhlbacher, J., Bringmann, G. |
| Zdroj: |
Journal of Natural Products; August 2002, Vol. 65 Issue: 8 p1117-1121, 5p |
| Abstrakt: |
The novel phenylanthraquinones 4-O-demethylknipholone-4-O-β-d-glucopyranoside (2) and gaboroquinones A (3) and B (4) were isolated from the African medicinal plant Bulbine frutescens. Biaryl 2 represents the first phenylanthraquinone glucoside, while 3 and 4 are the first side-chain-hydroxylated phenylanthraquinones. Their constitutions were determined by spectroscopic analysis, in particular by HMBC, HMQC, and ROESY NMR investigations, and by chemical transformations. The axial configurations were elucidated chemically, by deglucosylation of 2 and by side-chain deoxygenation of 3 and 4 to give the known phenylanthraquinones 4-O-demethylknipholone (5), isoknipholone (6), and knipholone (1), respectively, and chiroptically, by CD investigations. Compounds 2, 3, and 4 showed moderate to good antiplasmodial and antitrypanosomal activities in vitro. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
|
