In VitroAntimalarial Activity of Different Inhibitors of the Plasmodial Isoprenoid Synthesis Pathway

Autor: da Silva, Marcia F., Saito, Alexandre Y., Peres, Valnice J., Oliveira, Antonio C., Katzin, Alejandro M.
Zdroj: Antimicrobial Agents and Chemotherapy; May 2015, Vol. 59 Issue: 8 p5084-5087, 4p
Abstrakt: ABSTRACTPrevious studies have shown that fosmidomycin, risedronate, and nerolidol exert antimalarial activity in vitro. We included squalestatin, an inhibitor of the isoprenoid metabolism in Erwinia uredovora, and found that combinations of compounds which act on different targets of the plasmodial isoprenoid pathway possess important supra-additivity effects.
Databáze: Supplemental Index