The Frequency of Candidate Alleles for CYP2D6 Genotyping in the Japanese Population with an Additional Respect to the −1584C to G Substitution

Autor: Ikenaga, Yuka, Fukuda, Tsuyoshi, Fukuda, Kazuhiro, Nishida, Yuko, Naohara, Masakazu, Maune, Hiromi, Azuma, Junichi
Zdroj: Drug Metabolism and Pharmacokinetics; January 2005, Vol. 20 Issue: 2 p113-116, 4p
Abstrakt: The −1584C/G single nucleotide polymorphism (SNP) in the promoter region of CYP2D6was suggested to have the potential to influence CYP2D6 activity. In this report, we demonstrated the frequencies of −1584C to G substitution-related alleles, such as CYP2D6*2, CYP2D6*21, CYP2D6*35and CYP2D6*41, in the Japanese population. The frequencies of CYP2D6*2, *41and *21were 0.102, 0.026 and 0.005, respectively. We also showed a relationship between the SNP and other common alleles, CYP2D6*4, *5, *10, *14and *18. Interestingly, the SNP was detected in all three subjects carrying CYP2D6*14. This finding suggests the −1584G is included in the CYP2D6*14allele, which is a null-allele characteristic to the Japanese population. This report presents practical information on CYP2D6alleles that should be considered in the pharmacokinetic study of CYP2D6substrates in the Japanese population.
Databáze: Supplemental Index
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