| Autor: |
Lopatina, Ekaterina V., Kipenko, AV, Penniyaynen, VA, Pasatetskaya, NA, Djuric, D, Krylov, BV |
| Zdroj: |
Acta Physiologica Hungarica; June 2015, Vol. 102 Issue: 2 p137-142, 6p |
| Abstrakt: |
Homocysteine thiolactone was demonstrated to inhibit the growth of 10–12-day-old chicken embryo cardiac tissue explants at 7 × 10−9−1 × 10−3M concentrations in a dose-dependent manner. The maximal cardiotoxic effect of homocysteine thiolactone was detected at 1 × 10−3M, which corresponds to severe hyperhomocysteinemia. The results of experiments on culturing of cardiac tissue explants in the medium containing homocysteine thiolactone (1 × 10−3M) and ouabain at concentrations regulating the signal-transducing (1 × 10−10M) and pumping (1 × 10−8 M) functions of Na+,K+-ATPase indicate that the cardiotoxic effect of homocysteine thiolactone is supposed to result from inhibition of the Na+,K+-ATPase pumping function. |
| Databáze: |
Supplemental Index |
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