Multisite clinical trials in alcoholism treatment research: organizational, methodological and management issues.

Autor: Fuller, R K, Mattson, M E, Allen, J P, Randall, C L, Anton, R F, Babor, T F
Zdroj: Journal of Studies on Alcohol and Drugs, Supplement; December 1994, Vol. 12 Issue: 1, Supplement 1 p30-37, 8p
Abstrakt: Multisite clinical trials have two major advantages over single-site studies: the large sample size of multisite studies allows for adequate statistical power and better representativeness of the population being studied. However, they are more complex to implement than single-site studies. This article reviews previous multisite clinical trials of alcohol abuse and alcoholism, reasons for selecting a multisite design, management of such studies, and some statistical issues.
Databáze: Supplemental Index