Environmental Isolates of Azole-Resistant Aspergillus fumigatusin Germany

Autor: Bader, Oliver, Tünnermann, Jana, Dudakova, Anna, Tangwattanachuleeporn, Marut, Weig, Michael, Groß, Uwe
Zdroj: Antimicrobial Agents and Chemotherapy; April 2015, Vol. 59 Issue: 7 p4356-4359, 4p
Abstrakt: ABSTRACTAzole antifungal drug resistance in Aspergillus fumigatusis an emerging problem in several parts of the world. Here we investigated the distribution of such strains in soils from Germany. At a general positivity rate of 12%, most prevalently, we found strains with the TR34/L98H and TR46/Y121F/T289A alleles, dispersed along a corridor across northern Germany. Comparison of the distributions of resistance alleles and genotypes between environment and clinical samples suggests the presence of local clinical clusters.
Databáze: Supplemental Index