| Autor: |
Jerman, J C, Gray, J, Brough, S J, Ooi, L, Owen, D, Davis, J B, Smart, D |
| Zdroj: |
BJA: British Journal of Anaesthesia; December 2002, Vol. 89 Issue: 6 p882-887, 6p |
| Abstrakt: |
Anandamide, an endogenous lipid, activates both cannabinoid (CB(1)) and vanilloid (VR1) receptors, both of which are co-expressed in rat dorsal root ganglion (DRG) cells. Activation of either receptor results in analgesia but the relative contribution of CB(1) and VR1 in anandamide-induced analgesia remains controversial. Here we compare the in vitro pharmacology of recombinant and endogenous VR1 receptors using calcium imaging, in clonal and DRG cells, respectively. We also consider the contribution of CB(1) and VR1 receptors to anandamide-induced analgesia. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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