RELATIVE ROLES OF HALOTHANE AND DIETHYL ETHER WIHT AND WIHTOUT NORADRENALINE IN HAEMORRHAGIC HYPOVOLAEMIC SHOCK IN DOGS

Autor: PUNNOOSE, V. A., TANDAN, G. C., HATANGDI, V. S., IYENGAR, N. R. S.
Zdroj: BJA: British Journal of Anaesthesia; June 1969, Vol. 41 Issue: 6 p496-496, 1p
Abstrakt: Six groups of five mongrel dogs were used to evaluate the effects of diethyl ether and halothane in haemorrhagic shock and of noradrenaline infusion before blood replacement. Total blood loss remaining approximately comparable, dogs receiving halothane showed higher survival rates. Noradrenaline increased the mortality. Dogs under ether, with both forms of anaesthetic, and without anaesthesia, showed rapid rate of bleeding accompanied by severe tachycardia and delayed recovery. It is considered that halothane, by virtue of its vasodilator effect and absence of sympatho-adrenal stimulation, may improve tissue perfusion despite hypovolaemia, by minimizing vaso-constriction, by enhancing capillary vasomotion, and by reducing tissue anoxia and the resulting metabolic alterations.
Databáze: Supplemental Index