| Autor: |
Wong, Patricia C., Ruderman, Jon M., Krupin, Theodore, Goldenfeld, Mordechai, Rosenberg, Lisa F., Shields, M. Bruce, Ritch, Robert, Liebmann, Jeffrey M., Gieser, David K. |
| Zdroj: |
American Journal of Ophthalmology; February 1994, Vol. 117 Issue: 2 p149-154, 6p |
| Abstrakt: |
We examined the safety and efficacy of 5-fluorouracil in eyes with open-angle glaucoma undergoing combined cataract removal and filtration surgery. We randomly assigned one eye each of 24 patients to receive 5-fluorouracil (five injections of 5 mg during two weeks after surgery) and one eye each of 20 patients to comprise the control group. Preoperatively, the two groups had similar mean intraocular pressure (P = .8) and number of medications (P = .2). The mean intraocular pressure of the 5-fluorouracil group was 18.6 ± 1.1 mm Hg, with 2.5 ± 0.3 medications; that of the control group was 18.2 ± 1.2 mm Hg, with 2.2 ± 0.2 medications. One year postoperatively, intraocular pressure and the number of medications were significantly reduced by a similar amount in both groups of patients (5-fluorouracil, 14.2 ± 0.7 mm Hg, 0.8 ± 0.2 medications; controls, 14.3 ± 0.6 mm Hg, 1.0 ± 0.2 medications). Transient superficial punctate keratopathy occurred more frequently (P = .04) in the 5-fluorouracil group (16 of 24 eyes, 67%) than in the control group (seven of 20 eyes, 35%). In our randomized and prospective study, the adjunctive use of 5-fluorouracil did not result in improved control of intraocular pressure one year after combined surgery in eyes with open-angle glaucoma. |
| Databáze: |
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