| Autor: |
KAY, N. H., UPPINGTON, J., SEAR, J. W., ALLEN, M. C. |
| Zdroj: |
BJA: British Journal of Anaesthesia; August 1985, Vol. 57 Issue: 8 p736-736, 1p |
| Abstrakt: |
2,6-Diisopropyl phenol in a fat emulsion formulation (propofol) has been used to supplement 67% nitrous oxide in oxygen anaesthesia in 20 patients premedicated with morphine 0.15 mg kg-1and atropine 0.6 mg, and undergoing body surface surgery. Following an induction dose of propofol 2.5 mg kg-1, the mean maintenance dose was 73.4μg kg-1min-1. When compared with 10 patients receiving Althesin to supplement nitrous oxide in oxygen in a similar manner, recovery was considerably faster following propofol. The only major side-effect associated with the use of propofol was pain on injection in nine out of 20 patients. When the patients receiving propofol were compared with a second control group (n = 11) in whom anaesthesia was induced with thiopentone 4 mg kg-1and maintained with 1 % halothane and nitrous oxide in oxygen, the former group showed a significant (P<0.01) decrease in the plasma cortisol concentration 30 min after the induction of anaesthesia. However, by 3 h after induction, the cortisol concentration in both groups was not significantly different from the baseline (pre-induction) value. The mechanism of this decrease is not known. In vestigation of the influence of the fat emulsion on blood coagulation andfibrinolysis revealed no differences when compared with patients receiving Althesin. |
| Databáze: |
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