| Autor: |
Goin, Juan Carlos, Borda, Enri, Segovia, Amalia, Sterin-Borda, Leonor |
| Zdroj: |
Experimental Biology and Medicine; June 1991, Vol. 197 Issue: 2 p186-192, 7p |
| Abstrakt: |
We examined the possible role of altered humoral immunity in Chagas'disease by analyzing the effect of sera on the binding of radioligand to β-adrenoceptors during the course of human Trypanosoma cruziinfection. We described two circulating IgG which bind with myocardial β1- and spleen cell β2-adrenoceptor. Both chagasic IgG against β1- and β2-adrenoceptors increased intracellular levels of cAMP, which could be blocked by specific β1- and β2-adrenoceptor antagonists. The IgG against the β1-adrenoceptor inhibited the action of norepinephrine on the contractility of atria. We also found differences in the distribution of β1- and β2-adrenoceptor antibodies in the course of infection. The anti-β2-adrenoceptor IgG appears during the acute stage, peaks on the group with less than 10 years of infection, and then decreases. The prevalence of anti-β1-adrenergic antibody is low in the acute stage, but it increases over time since infection, being higher in the group with more than 15 years of infection. The probable pathogenic role of both β1- and β2-adrenergic chagasic antibodies is discussed. |
| Databáze: |
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