| Autor: |
Gangarosa, L. P., Park, N. H., Hill, J. M. |
| Zdroj: |
Experimental Biology and Medicine; March 1977, Vol. 154 Issue: 3 p439-443, 5p |
| Abstrakt: |
These experiments indicate that iontophoresis of IdUrd into neonatal mouse skin may be as effective as ip administration in blocking TdR metabolism including its incorporation into DNA of the skin. Also, IdUrd appeared to be incorporated into DNA. These results suggest that antiviral chemotherapy in surface tissues may be better accomplished by using ionto-phoretic assistance of penetration since the drug is delivered specifically at the desired site and the overall dose to the animal is small compared to systemic administration. We would expect that the drug which is administered by iontophoresis would probably act similarly on active virus-producing cells to prevent viral multiplication. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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