| Autor: |
Cannon, P. J., Symchych, P. S., Demartini, F. E. |
| Zdroj: |
Experimental Biology and Medicine; October 1968, Vol. 129 Issue: 1 p278-284, 7p |
| Abstrakt: |
Transverse sections of human kidney were obtained at autopsy, frozen, and subsequently analyzed for uric acid. In 15 of 18 kidneys, 14 of which were free of renal pathology, tissue urate concentrations increased progressively from the renal cortex to papillary tip. Similarly in 5 antidiuretic rhesus monkeys infused with a sodium urate solution, increasing corticomedullary urate gradients were found in frozen kidney slices. In hydrated monkeys similar infusions were not associated with the occurrence of a urate gradient. The data indicate that urate may undergo stratification in human and antidiuretic primate kidney with higher concentrations occurring in the renal medulla. Although the lack of microscopic evidence does not exclude urate microcrystallization in medullary interstitial tissue, the possibilities that urate may undergo either countercurrent multiplication as a consequence of reabsorption beyond proximal tubules or countercurrent exchange by the vasa recta after passive reabsorption in the collecting ducts are entertained. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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