| Autor: |
Cardona, Edward, Lessler, Milton A. |
| Zdroj: |
Experimental Biology and Medicine; February 1974, Vol. 145 Issue: 2 p663-668, 6p |
| Abstrakt: |
Lead acetate (1%) added to the diet of young, rapidly growing rats slowed their growth 20%. Blood lead averaged about 90 μg/100 ml for the first 8 weeks and then rose to 150 μg during weeks 11–23. In spite of the high blood-lead levels, hematologic signs of lead poisoning were sparse until the 8th and subsequent weeks. Reticulocytes isolated from the lead-fed rats had lowered oxidative activity for the first 9 weeks, and were significantly depressed below controls in the 12th-24th weeks. The ATPase activity of cell membranes isolated from reticulocytes of lead-fed rats was significantly depressed during the entire study, but catalase activity initially rose and then fell during the latter part of the experimental period. The metabolic disturbances observed in these reticulocytes reflect the deleterious effect of lead on red-cell precursors and red-cell development. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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