| Autor: |
Sephton, Robert G., De Abrew, Sunil |
| Zdroj: |
Experimental Biology and Medicine; July 1979, Vol. 161 Issue: 3 p402-406, 5p |
| Abstrakt: |
The iron-chelating agent desferrioxamine caused approximately 10-fold reductions in 67Ga vascular concentrations and substantial (~ × 2) reductions in 67Ga concentrations of other tissues when injected iv into mice at 2 hr after 67Ga injection. Given 48 hr post 67Ga however, its only noteworthy effect was on the vascular compartment. Tumor was distinguished from other soft tissues by high concentrations of cell-bound 67Ga, of which an appreciable fraction could be chelated and cleared by desferrioxamine given 2 hr after 67Ga. This fraction diminished with time and, at 48 hr, desferrioxamine caused no significant clearance of tumor-bound 67Ga. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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