Colony-Stimulating Activity in Cultures of Granulocytosis-lnducing Tumor1,2

Autor: Burlington, H., Cronkite, E. P., Laissue, J. A., Reincke, U., Shadduck, R. K.
Zdroj: Experimental Biology and Medicine; January 1977, Vol. 154 Issue: 1 p86-92, 7p
Abstrakt: A transplantable mouse mammary carcinoma-producing granulocytosis in host mice has been established in cell cultures. Colony-stimulating activity (CSA) is released to the medium by both monolayers and suspension cultures over sustained periods. The CSA is heat labile and nondialyzable with an apparent molecular weight > 30,000. It is neutralized by antibody to colony-stimulating factor (CSF), suggesting that the material produced in tumor cell cultures is in fact CSF.The authors are grateful for vital contributions made to this work by our collaborators, Betty Heldman, Michael Makar, Mildred Pavelec, Naomi Pappas, and Marie Susa.
Databáze: Supplemental Index