| Autor: |
Rahman, Yueh-Erh, Cerny, Elizabeth A., Tollaksen, Sandra L., Wright, Betty Jean, Nance, Sharron L., Thomson, John F. |
| Zdroj: |
Experimental Biology and Medicine; September 1974, Vol. 146 Issue: 4 p1173-1176, 4p |
| Abstrakt: |
Actinomycin D, when encapsulated within liposomes, is less toxic to mice than the nonencapsulated form. A single dose (0.75 mg/kg) or multiple doses (1 × 0.50, 4 × 0.25 mg/kg) significantly increased the mean survival time of mice inoculated with Ehrlich ascites tumor cells. Liposomes containing actinomycin D were found in tumor cells and cell degeneration and death were subsequently observed. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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